Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier

被引：40

作者：

Kastin, AJ

Akerstrom, V

Pan, WH

机构：

[1] VA Med Ctr, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, New Orleans, LA 70112 USA

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 114卷 / 02期

关键词：

interleukin-10; cytokine; blood-brain barrier; lipophilicity; hydrogen bonding;

D O I：

10.1016/S0169-328X(03)00167-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that I-125-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted. Published by Elsevier Science B.V.

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收藏

页码：168 / 171

页数：4

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