Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors

被引：63

作者：

Tao, LH ^{[1
]}

Yang, SM ^{[1
]}

Xie, M ^{[1
]}

Kramer, PM ^{[1
]}

Pereira, MA ^{[1
]}

机构：

[1] Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA

来源：

CANCER LETTERS | 2000年 / 158卷 / 02期

关键词：

dichloroacetic acid; trichloroacetic acid; mouse liver tumor; c-jun; c-myc; DNA methylation;

D O I：

10.1016/S0304-3835(00)00518-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. Methylation of the c-jun and c myc genes, expression of bath genes and DNA methyltransferase (DNA MTase) activity were determined in liver tumors initiated by N-methyl-N-nitrosourea and promoted by DCA and TCA in female B6C3F1 mice. Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. DNA MTase activity was increased in tumors while decreased in non-involved liver. Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：185 / 193

页数：9

共 48 条

[41]

Tao LH, 1999, J BIOCHEM MOL TOXIC, V13, P231

[42] Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-jun and c-myc protooncogenes in mouse liver:: Prevention by methionine [J].