Epigenetic Transitions in Germ Cell Development and Meiosis

被引：181

作者：

Kota, Satya K. ^{[1
,2
]}

Feil, Robert ^{[1
,2
]}

机构：

[1] CNRS, Inst Mol Genet, UMR5535, F-34293 Montpellier, France

[2] Univ Montpellier 1 & 2, F-34293 Montpellier, France

来源：

DEVELOPMENTAL CELL | 2010年 / 19卷 / 05期

关键词：

IMPRINTING CONTROL REGIONS; MATERNAL GENOMIC IMPRINTS; X-CHROMOSOME INACTIVATION; DE-NOVO METHYLATION; MEIOTIC RECOMBINATION; DNA METHYLATION; HISTONE H3; DROSOPHILA-MELANOGASTER; MAMMALIAN MEIOSIS; HUMAN SPERM;

D O I：

10.1016/j.devcel.2010.10.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Germ cell development is controlled by unique gene expression programs and involves epigenetic reprogramming of histone modifications and DNA methylation The central event is meiosis, during which homologous chromosomes pair and recombine, processes that involve histone alterations At unpaired regions, chromatin is repressed by meiotic silencing After meiosis, male germ cells undergo chromatin remodeling, including histone-to-protamine replacement Male and female germ cells are also differentially marked by parental imprints, which contribute to sex determination in insects and mediate genomic imprinting in mammals Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies

引用

页码：675 / 686

页数：12

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