The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction

被引：73

作者：

Schlegel, A

Lisanti, MP

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Albert Einstein Comprehens Canc Ctr, Bronx, NY 10461 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2001年 / 12卷 / 01期

关键词：

caveolin; caveolae; signal transduction; cancer; muscular dystrophy;

D O I：

10.1016/S1359-6101(00)00022-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：41 / 51

页数：11

相关论文

共 98 条

[81] CAVEOLIN MOVES FROM CAVEOLAE TO THE GOLGI-APPARATUS IN RESPONSE TO CHOLESTEROL OXIDATION [J].

SMART, EJ ;

YING, YS ;

CONRAD, PA ;

ANDERSON, RGW .

JOURNAL OF CELL BIOLOGY, 1994, 127 (05) :1185-1197

[82]

Smart EJ, 1999, MOL CELL BIOL, V19, P7289

[83] A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane [J].

Smart, EJ ;

Ying, YS ;

Donzell, WC ;

Anderson, RGW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) :29427-29435

[84] Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains - Detergent-free purification of caveolae membranes [J].

Song, KS ;

Li, SW ;

Okamoto, T ;

Quilliam, LA ;

Sargiacomo, M ;

Lisanti, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (16) :9690-9697

[85] Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells - Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins [J].

Song, KS ;

Scherer, PE ;

Tang, ZL ;

Okamoto, T ;

Li, SW ;

Chafel, M ;

Chu, C ;

Kohtz, DS ;

Lisanti, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (25) :15160-15165

[86]

Song KS, 1997, CELL MOL BIOL, V43, P293

[87] Mutational analysis of the properties of caveolin-1 - A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions [J].

Song, KS ;

Tang, ZL ;

Li, SW ;

Lisanti, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) :4398-4403

[88] Caveolin-3 directly interacts with the C-terminal tail of β-dystroglycan -: Identification of a central WW-like domain within caveolin family members [J].

Sotgia, F ;

Lee, JK ;

Das, K ;

Bedford, M ;

Petrucci, TC ;

Macioce, P ;

Sargiacomo, M ;

Bricarelli, FD ;

Minetti, C ;

Sudol, M ;

Lisanti, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :38048-38058

[89] Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle [J].

Tang, ZL ;

Scherer, PE ;

Okamoto, T ;

Song, K ;

Chu, C ;

Kohtz, DS ;

Nishimoto, I ;

Lodish, HF ;

Lisanti, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) :2255-2261

[90] Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles [J].

Thiele, C ;

Hannah, MJ ;

Fahrenholz, F ;

Huttner, WB .

NATURE CELL BIOLOGY, 2000, 2 (01) :42-49

← 1 2 3 4 5 6 7 8 9 10 →