Antitumor activities of heteropolysaccharides of Poria cocos mycelia from different strains and culture media

被引：111

作者：

Jin, Y

Zhang, LN ^{[1
]}

Zhang, M

Chen, L

Cheung, PCK

Oi, VEC

Lin, YL

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biol, Hong Kong, Hong Kong, Peoples R China

[3] Jianghan Univ, Coll Chem & Environm Engn, Wuhan 430056, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2003年 / 338卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Poria cocos mycelia; heteropolysaccharide; antitumor activity; protein-bound alpha-glucan; correlation of structure to bioactivity;

D O I：

10.1016/S0008-6215(03)00198-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten water-soluble heteropolysaccharide fractions were isolated from Poria cocos mycelia cultured from one wild and one cultivated strain in two identical culture media differing only in one component: either corn steep liquor or bran extract. The chemical compositions, including monosaccharide profile, protein content, and molecular mass M-w of the mycelial polysaccharides were determined. Both the in vitro and in vivo antitumor activities of the heteropolysaccharides were evaluated and compared. The heteropolysaccharides from Poria cocos mycelia cultured with the wild strain in a medium containing corn steep liquor exhibited the highest antitumor activities against Sarcoma 180 in vivo. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1517 / 1521

页数：5