Negative regulation of cytokine signaling and inflammatory diseases

被引：29

作者：

Inagaki-Ohara, K ^{[1
]}

Hanada, T ^{[1
]}

Yoshimura, A ^{[1
]}

机构：

[1] Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Higashi Ku, Fukuoka 8128582, Japan

来源：

CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 04期

关键词：

D O I：

10.1016/S1471-4892(03)00070-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activators of transcription (STATs). The cytokine-inducible SH2 proteins (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory system. Several recent advances have been made in this field, including treatment of inflammatory diseases by modulating extracellular and intracellular signaling pathways.

引用

页码：435 / 442

页数：8

共 91 条

[51] Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas [J].

Nagai, H ;

Kim, YS ;

Konishi, N ;

Baba, M ;

Kubota, T ;

Yoshimura, A ;

Emi, M .

CANCER LETTERS, 2002, 186 (01) :59-65

[52] Structure and function of a new STAT-induced STAT inhibitor [J].

Naka, T ;

Narazaki, M ;

Hirata, M ;

Matsumoto, T ;

Minamoto, S ;

Aono, A ;

Nishimoto, N ;

Kajita, T ;

Taga, T ;

Yoshizaki, K ;

Akira, S ;

Kishimoto, T .

NATURE, 1997, 387 (6636) :924-929

[53] SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo [J].

Naka, T ;

Tsutsui, H ;

Fujimoto, M ;

Kawazoe, Y ;

Kohzaki, H ;

Morita, Y ;

Nakagawa, R ;

Narazaki, M ;

Adachi, K ;

Yoshimoto, T ;

Nakanishi, K ;

Kishimoto, T .

IMMUNITY, 2001, 14 (05) :535-545

[54] Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice [J].

Naka, T ;

Matsumoto, T ;

Narazaki, M ;

Fujimoto, M ;

Morita, Y ;

Ohsawa, Y ;

Saito, H ;

Nagasawa, T ;

Uchiyama, Y ;

Kishimoto, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15577-15582

[55] SOCS-1 participates in negative regulation of LPS responses [J].

Nakagawa, R ;

Naka, T ;

Tsutsui, H ;

Fujimoto, M ;

Kimura, A ;

Abe, T ;

Seki, E ;

Sato, S ;

Takeuchi, O ;

Takeda, K ;

Akira, S ;

Yamanishi, K ;

Kawase, I ;

Nakanishi, K ;

Kishimoto, T .

IMMUNITY, 2002, 17 (05) :677-687

[56] Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 [J].

Nicholson, SE ;

De Souza, D ;

Fabri, LJ ;

Corbin, J ;

Willson, TA ;

Zhang, JG ;

Silva, A ;

Asimakis, M ;

Farley, A ;

Nash, AD ;

Metcalf, D ;

Hilton, DJ ;

Nicola, NA ;

Baca, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6493-6498

[57] IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways [J].

O'Farrell, AM ;

Liu, Y ;

Moore, KW ;

Mui, ALF .

EMBO JOURNAL, 1998, 17 (04) :1006-1018

[58] Up-regulation of the IL-12 receptor β2 chain in Crohn's disease [J].

Parrello, T ;

Monteleone, G ;

Cucchiara, S ;

Monteleone, I ;

Sebkova, L ;

Doldo, P ;

Luzza, F ;

Pallone, F .

JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :7234-7239

[59] Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling [J].

Pezet, A ;

Favre, H ;

Kelly, PA ;

Edery, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (35) :24497-24502

[60] Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 [J].

Roberts, AW ;

Robb, L ;

Rakar, S ;

Hartley, L ;

Cluse, L ;

Nicola, NA ;

Metcalf, D ;

Hilton, DJ ;

Alexander, WS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9324-9329

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