Microgravity and its implications for fermentation biotechnology

被引:31
作者
Klaus, DM [1 ]
机构
[1] Univ Colorado, Dept Aerosp Engn Sci, BioServe Space Technol, Boulder, CO 80309 USA
关键词
D O I
10.1016/S0167-7799(98)01197-4
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Fermentation processes are highly dependent upon physical and chemical environmental parameters, many of which are influenced by gravity. Extending biotechnology into the realm of space flight provides researchers with an opportunity to investigate the role that gravity plays in natural growth processes. Physical factors governing cell sedimentation, nutrient mixing and byproduct dispersion are altered in the absence of the constant sedimenting force of gravity. In addition, space flight has also been shown to give rise to a wide variety of indirect consequences associated with the physiology of the organisms themselves.
引用
收藏
页码:369 / 373
页数:5
相关论文
共 31 条
[11]  
Kacena M, 1997, MICROGRAVITY SCI TEC, V10, P58
[12]   Investigation of space flight effects on Escherichia coli and a proposed model of underlying physical mechanisms [J].
Klaus, D ;
Simske, S ;
Todd, P ;
Stodieck, L .
MICROBIOLOGY-SGM, 1997, 143 :449-455
[13]   Functional weightlessness during clinorotation of cell suspensions [J].
Klaus, DM ;
Todd, P ;
Schatz, A .
LIFE SCIENCES: MICROGRAVITY RESEARCH, 1998, 21 (8-9) :1315-1318
[14]   The effects of space flight on the production of monorden by Humicola fuscoatra WC5157 in solid-state fermentation [J].
Lam, KS ;
Mamber, SW ;
Pack, EJ ;
Forenza, S ;
Fernandes, PB ;
Klaus, DM .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1998, 49 (05) :579-583
[15]  
MANKO VG, 1987, 392214 NASA, P70
[17]   Recent advances in the microgravity crystallization of biological macromolecules [J].
McPherson, A .
TRENDS IN BIOTECHNOLOGY, 1997, 15 (06) :197-200
[18]  
MCPHERSON A, 1993, MICROGRAVITY SCI TEC, V1, P101
[19]   GROWTH AND DIFFERENTIATION OF BACILLUS-SUBTILIS UNDER MICROGRAVITY [J].
MENNIGMANN, HD ;
LANGE, M .
NATURWISSENSCHAFTEN, 1986, 73 (07) :415-417
[20]  
MENNIGMANN HD, 1994, P 5 EUR S LIF SCI RE, P83