Peroxisome proliferator-activated receptor δ controls muscle development and oxydative capability

被引:423
作者
Luquet, S
Lopez-Soriano, J
Holst, D
Fredenrich, A
Melki, J
Rassoulzadegan, M
Grimaldi, PA
机构
[1] Univ Nice, Ctr Biochim, INSERM, U470, F-06108 Nice 2, France
[2] Hop Louis Pasteur, Serv Diabetol Endocrinol, F-06002 Nice, France
[3] Genopole, INSERM, EMI 9913, F-91057 Evry, France
关键词
muscle development; lipid metabolism; hyperplasia; fiber typing; Cre-Lox transgenesis;
D O I
10.1096/fj.03-0269fje
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors exerting several functions in development and metabolism. The physiological functions of PPARdelta remain elusive. By using a CRE-Lox recombination approach, we generated an animal model for muscle-specific PPARdelta overexpression to investigate the role of PPARdelta in this tissue. Muscle-specific PPARdelta overexpression results in a profound change in fiber composition due to hyperplasia and/or shift to more oxidative fiber and, as a consequence, leads to the increase of both enzymatic activities and genes implicated in oxidative metabolism. These changes in muscle are accompanied by a reduction of body fat mass, mainly due to a large reduction of adipose cell size. Furthermore, we demonstrate that endurance exercise promotes an accumulation of PPARdelta protein in muscle of wild-type animals. Collectively, these results suggest that PPARdelta plays an important role in muscle development and adaptive response to environmental changes, such as training exercise. They strongly support the idea that activation of PPARdelta could be beneficial in prevention of metabolic disorders, such as obesity or type 2 diabetes.
引用
收藏
页码:2299 / +
页数:18
相关论文
共 38 条
[1]   Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse [J].
Allen, DL ;
Harrison, BC ;
Maass, AH ;
Bell, ML ;
Byrnes, WC ;
Leinwand, LA .
JOURNAL OF APPLIED PHYSIOLOGY, 2001, 90 (05) :1900-1908
[2]   CLONING OF A PROTEIN THAT MEDIATES TRANSCRIPTIONAL EFFECTS OF FATTY-ACIDS IN PREADIPOCYTES - HOMOLOGY TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS [J].
AMRI, EZ ;
BONINO, F ;
AILHAUD, G ;
ABUMRAD, NA ;
GRIMALDI, PA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (05) :2367-2371
[3]   Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice [J].
Barton, ER ;
Morris, L ;
Musaro, A ;
Rosenthal, N ;
Sweeney, HL .
JOURNAL OF CELL BIOLOGY, 2002, 157 (01) :137-147
[4]   Alterations of peroxisome proliferator-activated receptor δ activity affect fatty acid-controlled adipose differentiation [J].
Bastie, C ;
Luquet, S ;
Holst, D ;
Jehl-Pietri, C ;
Grimaldi, PA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (49) :38768-38773
[5]   Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat [J].
Braissant, O ;
Foufelle, F ;
Scotto, C ;
Dauca, M ;
Wahli, W .
ENDOCRINOLOGY, 1996, 137 (01) :354-366
[6]   PPARγ is a very low-density lipoprotein sensor in macrophages [J].
Chawla, A ;
Lee, CH ;
Barak, Y ;
He, WM ;
Rosenfeld, J ;
Liao, D ;
Han, J ;
Kang, H ;
Evans, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1268-1273
[7]   Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy [J].
Cifuentes-Diaz, C ;
Frugier, T ;
Tiziano, FD ;
Lacéne, E ;
Roblot, N ;
Joshi, V ;
Moreau, MH ;
Melki, J .
JOURNAL OF CELL BIOLOGY, 2001, 152 (05) :1107-1114
[8]   Peroxisome proliferator-activated receptors: insight into multiple cellular functions [J].
Escher, P ;
Wahli, W .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2000, 448 (02) :121-138
[9]   Murine spermatogonial stem cells: targeted transgene expression and purification in an active state [J].
Giuili, G ;
Tomljenovic, A ;
Labrecque, N ;
Oulad-Abdelghani, M ;
Rassoulzadegan, M ;
Cuzin, F .
EMBO REPORTS, 2002, 3 (08) :753-759
[10]   Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome-proliferators-activated receptor (PPAR) [J].
Hertz, R ;
Berman, I ;
Keppler, D ;
BarTana, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 235 (1-2) :242-247