Identifying biological themes within lists of genes with EASE

被引：1391

作者：

Hosack, DA

Dennis, G

Sherman, BT

Lane, HC

Lempicki, RA

机构：

[1] SAIC Frederick Inc, Lab Immunopathogenesis & Bioinformat, Frederick, MD 21702 USA

[2] NIAID, Clin & Mol Retrovirol Sect, NIH, Bethesda, MD 20892 USA

来源：

GENOME BIOLOGY | 2003年 / 4卷 / 10期

关键词：

D O I：

10.1186/gb-2003-4-10-r70

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data. The biological themes returned by EASE recapitulate manually determined themes in previously published gene lists and are robust to varying methods of normalization, intensity calculation and statistical selection of genes. EASE is a powerful tool for rapidly converting the results of functional genomics studies from 'genes' to 'themes'.

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页数：8

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