Proteins in action: the physics of structural fluctuations and conformational changes

被引：104

作者：

Parak, FG ^{[1
]}

机构：

[1] TUM, Phys Dept E17, D-85747 Garching, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/j.sbi.2003.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural dynamics is essential for the biological function of proteins. Results from new experimental techniques should be compared with those from previous experiments in order to obtain a consistent picture of the physics of intramolecular fluctuations and conformational changes. The high intensity and time structure of synchrotron radiation have made possible time-resolved X-ray structure analysis and the determination of phonon density spectra through the Mossbauer effect. By combining results from Mossbauer absorption spectroscopy, incoherent neutron scattering, low-temperature crystallography and optical spectroscopy, a physical picture of protein dynamics emerges.

引用

页码：552 / 557

页数：6

共 40 条

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