Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility

被引:135
作者
Weedon, MN
Schwarz, PEH
Horikawa, Y
Iwasaki, N
Illig, T
Holle, R
Rathmann, W
Selisko, T
Schulze, J
Owen, KR
Evans, J
Bosque-Plata, LD
Hitman, G
Walker, M
Levy, JC
Sampson, M
Bell, GI
McCarthy, MI
Hattersley, AT
Frayling, TM
机构
[1] Peninsula Med Sch, Dept Diabet Res & Vasc Med, Exeter, Devon, England
[2] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Endocrinopathies & Metab Dis, D-8027 Dresden, Germany
[3] Gunma Univ, Inst Mol & Cellular Regulat, Dept Cell Biol, Gunma, Japan
[4] Tokyo Womens Med Univ, Ctr Diabet, Tokyo, Japan
[5] GSF, Natl Res Ctr Environm & Hlth, Inst Epidemiol, Neuherberg, Germany
[6] GSF, Natl Res Ctr Environm & Hlth, Inst Hlth Econ & Hlth Care Management, Neuherberg, Germany
[7] German Diabet Res Inst, Dept Biometry & Epidemiol, Dusseldorf, Germany
[8] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA
[9] Univ London, Queen Mary Sch Med & Dent, Barts & London, Dept Diabet & Metab Med, London, England
[10] Med Sch Newcastle Upon Tyne, Dept Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[11] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
[12] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
[13] Univ Oxford, Radcliffe Infirm, Diabet Res Labs, Oxford OX2 6HE, England
[14] Ctr Diabet, Norwich, Norfolk, England
关键词
D O I
10.1086/379285
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:1208 / 1212
页数:5
相关论文
共 24 条
[11]   CAPN10 alleles are associated with polycystic ovary syndrome [J].
Gonzalez, A ;
Abril, E ;
Roca, A ;
Aragón, MJ ;
Figueroa, MJ ;
Velarde, P ;
Royo, JL ;
Real, LM ;
Ruiz, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (08) :3971-3976
[12]   A genome-wide search for human non-insulin dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 [J].
Hanis, CL ;
Boerwinkle, E ;
Chakraborty, R ;
Ellsworth, DL ;
Concannon, P ;
Stirling, B ;
Morrison, VA ;
Wapelhorst, B ;
Spielman, RS ;
GogolinEwens, KJ ;
Shephard, JM ;
Williams, SR ;
Risch, N ;
Hinds, D ;
Iwasaki, N ;
Ogata, M ;
Omori, Y ;
Petzold, C ;
Rietzsch, H ;
Schroder, HE ;
Schulze, J ;
Cox, NJ ;
Menzel, S ;
Boriraj, VV ;
Chen, X ;
Lim, LR ;
Lindner, T ;
Mereu, LE ;
Wang, YQ ;
Xiang, K ;
Yamagata, K ;
Yang, Y ;
Bell, GI .
NATURE GENETICS, 1996, 13 (02) :161-166
[13]   Absence of association of type 2 diabetes with CAPN10 and PC-1 polymorphisms in Oji-Cree [J].
Hegele, RA ;
Harris, SB ;
Zinman, B ;
Hanley, AJG ;
Cao, H .
DIABETES CARE, 2001, 24 (08) :1498-1499
[14]   Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus [J].
Horikawa, Y ;
Oda, N ;
Cox, NJ ;
Li, XQ ;
Orho-Melander, M ;
Hara, M ;
Hinokio, Y ;
Lindner, TH ;
Mashima, H ;
Schwarz, PEH ;
del Bosque-Plata, L ;
Horikawa, Y ;
Oda, Y ;
Yoshiuchi, I ;
Colilla, S ;
Polonsky, KS ;
Wei, S ;
Concannon, P ;
Iwasaki, N ;
Schulze, T ;
Baier, LJ ;
Bogardus, C ;
Groop, L ;
Boerwinkle, E ;
Hanis, CL ;
Bell, GI .
NATURE GENETICS, 2000, 26 (02) :163-175
[15]   Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese [J].
Horikawa, Y ;
Oda, N ;
Yu, L ;
Imamura, S ;
Fujiwara, K ;
Makino, M ;
Seino, Y ;
Itoh, M ;
Takeda, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :244-247
[16]   An E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARγ Pro12Ala variant [J].
Love-Gregory, L ;
Wasson, J ;
Lin, J ;
Skolnick, G ;
Suarez, B ;
Permutt, MA .
DIABETOLOGIA, 2003, 46 (01) :136-137
[17]   Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population [J].
Malecki, MT ;
Moczulski, DK ;
Klupa, T ;
Wanic, K ;
Cyganek, K ;
Frey, J ;
Sieradzki, J .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2002, 146 (05) :695-699
[18]   The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes [J].
Nielsen, EMD ;
Hansen, L ;
Carstensen, B ;
Echwald, SM ;
Drivsholm, T ;
Glümer, C ;
Thorsteinsson, B ;
Borch-Johnsen, K ;
Hansen, T ;
Pedersen, O .
DIABETES, 2003, 52 (02) :573-577
[19]   Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels [J].
Orho-Melander, M ;
Klannemark, M ;
Svensson, MK ;
Ridderstråle, M ;
Lindgren, CM ;
Groop, L .
DIABETES, 2002, 51 (08) :2658-2664
[20]   Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians [J].
Rasmussen, SK ;
Urhammer, SA ;
Berglund, L ;
Jensen, JN ;
Hansen, L ;
Echwald, SM ;
Borch-Johnsen, K ;
Horikawa, Y ;
Mashima, H ;
Lithell, H ;
Cox, NJ ;
Hansen, T ;
Bell, GI ;
Pedersen, O .
DIABETES, 2002, 51 (12) :3561-3567