Chaperones and slow death - a recipe for tumor immunotherapy

被引：22

作者：

Calderwood, SK ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Hosp BIDMC, Dept Radiat Oncol, Boston, MA 02215 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2005年 / 23卷 / 02期

关键词：

D O I：

10.1016/j.tibtech.2004.12.011

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In an exciting recent paper Richard Vile and coworkers describe a novel approach to tumor immunotherapy based on the killing of a population of normal cells within an inflammatory environment. This approach builds on recent studies showing that the molecular chaperone Hsp70 can act at multiple stages during tumor antigen presentation to enhance the generation of CD8(+) T lymphocyte-mediated immunity and lead to regression of primary and metastatic tumors.

引用

页码：57 / 59

页数：3

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