Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer

被引：94

作者：

Castelli, C

Rivoltini, L

Rini, F

Belli, F

Testori, A

Maio, M

Mazzaferro, V

Coppa, J

Srivastava, PK

Parmiani, G

机构：

[1] Ist Nazl Studio & Cura Tumori, Unit Immunotherapy Human Tumors, I-20133 Milan, Italy

[2] Ist Nazl Studio & Cura Tumori, Unit Gen Surg, I-20133 Milan, Italy

[3] European Inst Oncol, I-20141 Milan, Italy

[4] Ctr Riferimento Oncol, Dept Med Oncol, Unit Canc Bioimmunotherapy, I-33081 Aviano, Italy

[5] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect dis, Farmington, CT USA

[6] Ist Nazl Studio & Cura Tumori, Unit Hepatobiliary & Gastropancreat Surg, I-20133 Milan, Italy

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2004年 / 53卷 / 03期

关键词：

heat shock proteins; cross-priming; vaccination; melanoma; colorectal cancer; peptides;

D O I：

10.1007/s00262-003-0481-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock proteins (HSPs) are a large family of proteins with different molecular weights and different intracellular localizations. These proteins undertake crucial functions in maintaining cell homeostasis, and therefore they have been conserved during evolution. Hsp70 and Grp94/gp96, due to their peptide chaperone capacity and their ability to actively interact with professional antigen-presenting cells (APCs), are also endowed with crucial immunological functions. The immunological properties of these proteins and their implications for vaccine in human cancer will be discussed. Immunological and clinical data of phase I/II studies in melanoma and colorectal cancer patients will be reviewed.

引用

页码：227 / 233

页数：7

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