Up for Mischief? IL-17/Th17 in the tumour microenvironment
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Maniati, E.
[1
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Soper, R.
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Queen Mary Univ London, Ctr Canc & Inflammat, Inst Canc, Barts & London Sch Med & Dent, London EC1M 6BQ, EnglandQueen Mary Univ London, Ctr Canc & Inflammat, Inst Canc, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Soper, R.
[1
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Hagemann, T.
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Queen Mary Univ London, Ctr Canc & Inflammat, Inst Canc, Barts & London Sch Med & Dent, London EC1M 6BQ, EnglandQueen Mary Univ London, Ctr Canc & Inflammat, Inst Canc, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Hagemann, T.
[1
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[1] Queen Mary Univ London, Ctr Canc & Inflammat, Inst Canc, Barts & London Sch Med & Dent, London EC1M 6BQ, England
The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation. An expanding body of literature implicates Th17 cells and their hallmark cytokine in both pro-and anti-tumourigenic processes. In this review we describe their biological activities and outline the reciprocal interactions between Th17 cells and other cells of the immune system. We also discuss the evidence regarding their dual role in the tumour microenvironment. An understanding of the processes that regulate the pro-or anti-tumour activities of Th17 cell and IL-17 will allow the development of more effective means for cancer immunotherapy. Oncogene (2010) 29, 5653-5662; doi:10.1038/onc.2010.367; published online 23 August 2010
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Ayyoub, Maha
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Deknuydt, Florence
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Deknuydt, Florence
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Raimbaud, Isabelle
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Raimbaud, Isabelle
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Dousset, Christelle
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Dousset, Christelle
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Leveque, Lucie
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Leveque, Lucie
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Bioley, Gilles
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Bioley, Gilles
;
Valmori, Danila
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Univ Nantes, Fac Med, F-44093 Nantes, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
机构:
Barts & London Queen Marys Sch Med & Dent, Ctr Translat Oncol, Inst Canc, John Vane Sci Ctr, London EC1M 6BQ, EnglandBarts & London Queen Marys Sch Med & Dent, Ctr Translat Oncol, Inst Canc, John Vane Sci Ctr, London EC1M 6BQ, England
机构:
Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Ayyoub, Maha
;
Deknuydt, Florence
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h-index: 0
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Deknuydt, Florence
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Raimbaud, Isabelle
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Raimbaud, Isabelle
;
Dousset, Christelle
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h-index: 0
机构:
Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Dousset, Christelle
;
Leveque, Lucie
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Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Leveque, Lucie
;
Bioley, Gilles
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Bioley, Gilles
;
Valmori, Danila
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
Univ Nantes, Fac Med, F-44093 Nantes, FranceCtr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France
机构:
Barts & London Queen Marys Sch Med & Dent, Ctr Translat Oncol, Inst Canc, John Vane Sci Ctr, London EC1M 6BQ, EnglandBarts & London Queen Marys Sch Med & Dent, Ctr Translat Oncol, Inst Canc, John Vane Sci Ctr, London EC1M 6BQ, England