Control of pseudohyphae formation in Saccharomyces cerevisiae

被引:207
作者
Gancedo, JM [1 ]
机构
[1] UAM, CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain
关键词
dimorphism; pseudohypha; invasive growth; yeast; Candida albicans; Saccharomyces cerevisiae;
D O I
10.1016/S0168-6445(00)00056-5
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Pseudohyphal growth in both haploid and diploid strains of Saccharomyces cerevisiae reflects concerted changes in different cellular processes: budding pattern, cell elongation and cell adhesion. These changes are triggered by environmental signals and are controlled by several pathways which act in parallel. Nitrogen deprivation, and possibly other stresses, activate a MAP kinase cascade which has the transcription factor Ste12 as its final target. A cAMP-dependent pathway, in which the protein kinase Tpk2 plays a specific role, is also required for the morphogenetic switch. Both pathways contribute to modulate the expression of the MUC1/FLO11 gene which encodes a cell-surface flocculin required for pseudohyphal and invasive growth. The MAP kinase cascade could also control the activity of the cyclin/ Cdc28 complexes which affect both the budding pattern of yeast and cell elongation. A further protein which stimulates filamentous growth in S, cerevisiae is Phd1, although its mode of action is unknown, it may be regulated by a cAMP-dependent protein kinase, as occurs with the homologous protein Efg1 from Candida albicans, which is required for the formation of true hyphae. Morphogenesis in different yeast genera share common elements, but there are also important differences. Although a complete picture cannot yet be drawn, partial models may be proposed for the interaction of the regulatory pathways, both in the case of S. cerevisiae and in that of C. albicans. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:107 / 123
页数:17
相关论文
共 135 条
[31]   Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae [J].
Gagiano, M ;
van Dyk, D ;
Bauer, FF ;
Lambrechts, MG ;
Pretorius, IS .
MOLECULAR MICROBIOLOGY, 1999, 31 (01) :103-116
[32]   Divergent regulation of the evolutionarily closely related promoters of the Saccharomyces cerevisiae STA2 and MUC1 genes [J].
Gagiano, M ;
Van Dyk, D ;
Bauer, FF ;
Lambrechts, MG ;
Pretorius, IS .
JOURNAL OF BACTERIOLOGY, 1999, 181 (20) :6497-6508
[33]   Cloning and expression of a gene encoding an integrin-like protein in Candida albicans [J].
Gale, C ;
Finkel, D ;
Tao, NJ ;
Meinke, M ;
McClellan, M ;
Olson, J ;
Kendrick, K ;
Hostetter, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :357-361
[34]   Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1 [J].
Gale, CA ;
Bendel, CM ;
McClellan, M ;
Hauser, M ;
Becker, JM ;
Berman, J ;
Hostetter, MK .
SCIENCE, 1998, 279 (5355) :1355-1358
[35]   Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth [J].
Gavrias, V ;
Andrianopoulos, A ;
Gimeno, CJ ;
Timberlake, WE .
MOLECULAR MICROBIOLOGY, 1996, 19 (06) :1255-1263
[36]   INDUCTION OF PSEUDOHYPHAL GROWTH BY OVEREXPRESSION OF PHD1, A SACCHAROMYCES-CEREVISIAE GENE-RELATED TO TRANSCRIPTIONAL REGULATORS OF FUNGAL DEVELOPMENT [J].
GIMENO, CJ ;
FINK, GR .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) :2100-2112
[37]   UNIPOLAR CELL DIVISIONS IN THE YEAST SACCHAROMYCES-CEREVISIAE LEAD TO FILAMENTOUS GROWTH - REGULATION BY STARVATION AND RAS [J].
GIMENO, CJ ;
LJUNGDAHL, PO ;
STYLES, CA ;
FINK, GR .
CELL, 1992, 68 (06) :1077-1090
[38]   CAMP REGULATES MORPHOGENESIS IN THE FUNGAL PATHOGEN USTILAGO-MAYDIS [J].
GOLD, S ;
DUNCAN, G ;
BARRETT, K ;
KRONSTAD, J .
GENES & DEVELOPMENT, 1994, 8 (23) :2805-2816
[39]  
GUILLIERMOND A, 1920, YEASTS
[40]   Dissecting the regulatory circuitry of a eukaryotic genome [J].
Holstege, FCP ;
Jennings, EG ;
Wyrick, JJ ;
Lee, TI ;
Hengartner, CJ ;
Green, MR ;
Golub, TR ;
Lander, ES ;
Young, RA .
CELL, 1998, 95 (05) :717-728