amino acids and derivatives;
asymmetric synthesis;
enzymes and enzyme reactions;
reduction;
D O I:
10.1016/S0040-4039(98)01123-X
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Porcine liver eaterase (PLE)- or rabbit liver eaterase (RLE)-catalyzed hydrolysis of the pro-S eater group of diethyl alpha-alkyl-alpha -(benzyloxycarbonylamino)malonate s 2a-e afforded (R)-ethyl alpha-alkyl-alpha -(benzyloxycarbonylamino)malonates 3a-e each in excellent enantiomeric excess. Enantiodivergent reductions of these acid eaters 3a-e readily furnished both the corresponding enantiomeric alpha-substituted serines (R)- and (S)-5a-c. (C) 1998 Elsevier Science Ltd. All rights reserved.