Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent

被引：167

作者：

Li, Xinming ^{[1
]}

Li, Jiayang ^{[1
]}

Gao, Yuan ^{[1
]}

Kuang, Yi ^{[1
]}

Shi, Junfeng ^{[1
]}

Xu, Bing ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, 415 South St, Waltham, MA 02454 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 50期

关键词：

TARGETED DRUG-DELIVERY; 5-AMINOSALICYLIC ACID; ORGANIC LIQUIDS; PEPTIDE; COLON; GELS; BIOMATERIALS; SCAFFOLDS; MEDICINE; SURFACES;

D O I：

10.1021/ja109269v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.

引用

页码：17707 / 17709

页数：3

共 49 条

[1] Hydrogels for tissue engineering and delivery of tissue-inducing substances [J].

Baroli, Biancamaria .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 96 (09) :2197-2223

[2] A Reductive Trigger for Peptide Self-Assembly and Hydrogelation [J].

Bowerman, Charles J. ;

Nilsson, Bradley L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (28) :9526-9527

[3] Self-assembling materials for therapeutic delivery [J].

Branco, Monica C. ;

Schneider, Joel P. .

ACTA BIOMATERIALIA, 2009, 5 (03) :817-831

[4] Synthesis, characterization and in vitro release of 5-aminosalicylic acid and 5-acetyl aminosalicylic acid of polyanhydride - P(CBFAS) [J].

Cai, QX ;

Zhu, KJ ;

Chen, D ;

Gao, LP .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2003, 55 (02) :203-208

[5]

Chourasia MK, 2003, J PHARM PHARM SCI, V6, P33

[6] Aqueous self-assembly of unsymmetric peptide bolaamphiphiles into nanofibers with hydrophilic cores and surfaces [J].

Claussen, RC ;

Rabatic, BM ;

Stupp, SI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (42) :12680-12681

[7] RETRACTED: Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid with D-phenylaianine for colon specific drug delivery in inflammatory bowel disease (Retracted article. See vol. 19, pg. 1035, 2009) [J].

Dhaneshwar, Suneela S. ;

Gairola, Neha ;

Kandpal, Mini ;

Bhatt, Lokesh ;

Vadnerkar, Gaurav ;

Kadam, S. S. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (07) :1897-1902

[8] Hydrogels for tissue engineering: scaffold design variables and applications [J].

Drury, JL ;

Mooney, DJ .

BIOMATERIALS, 2003, 24 (24) :4337-4351

[9]

Ebersole JL, 2008, MOLECULES, V13, P771

[10] Water gelation by small organic molecules [J].

Estroff, LA ;

Hamilton, AD .

CHEMICAL REVIEWS, 2004, 104 (03) :1201-1217

← 1 2 3 4 5 →