Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent

被引:167
作者
Li, Xinming [1 ]
Li, Jiayang [1 ]
Gao, Yuan [1 ]
Kuang, Yi [1 ]
Shi, Junfeng [1 ]
Xu, Bing [1 ]
机构
[1] Brandeis Univ, Dept Chem, 415 South St, Waltham, MA 02454 USA
关键词
TARGETED DRUG-DELIVERY; 5-AMINOSALICYLIC ACID; ORGANIC LIQUIDS; PEPTIDE; COLON; GELS; BIOMATERIALS; SCAFFOLDS; MEDICINE; SURFACES;
D O I
10.1021/ja109269v
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.
引用
收藏
页码:17707 / 17709
页数:3
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