Automating combinatorial chemistry: A primer on benchtop robotic systems

被引：10

作者：

Hardin, JH

Smietana, FR

机构：

[1] Lilly Research Laboratories, A Division of Eli Lilly and Co., Lilly Corporate Center, Indianapolis

来源：

MOLECULAR DIVERSITY | 1996年 / 1卷 / 04期

关键词：

robotics; automation; combinatorial chemistry;

D O I：

10.1007/BF01715532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Benchtop robotic systems are inexpensive, flexible automation tools with potential applications in a wide array of disciplines such as combinatorial chemistry, high-throughput screening, and genomics. We explain the basic components of a benchtop system and explore factors to consider when purchasing or customizing a robot, such as automation benefits, vendor selection, and current system limitations. Issues involving system specification, software design, and hardware customization are then discussed. Additionally, system optimization, validation, and support are detailed. Given a properly designed and implemented system, the combinatorial laboratory can markedly increase compound synthesis and purification.

引用

页码：270 / 274

页数：5

共 15 条

[1] Advanced ChemTech, 5609 Fern Valley Road, Louisville, KY 40228, U.S.A
[2] Bohdan Automation, Inc., 1500 McCormick Boulevard, Mundelein, IL 60060, U.S.A
[3] Science Applications International Corporation (SAIC), 10260 Campus Point Drive, MS C4, San Diego, CA 92121, U.S.A
[4] TomTec, 607 Harborview Road, Orange, CT 06477, U.S.A
[5] Tecan U.S. SLT Lab Instruments, P.O. Box 13953, Research Triangle Park, NC 27709, U.S.A
[6] Argonaut Technologies, Inc., 887 Industrial Road, Suite G, San Carlos, CA 94070, U.S.A
[7] CombiChem, Inc., 9050 Camino, Santa Fe, San Diego, CA 92121, U.S.A
[8] Beckman Instruments, Inc., 846 Algonquin Road, Schaumburg, IL 60173, U.S.A
[9] Hamilton Co., 4970 Energy Way, Reno, NV 89502, U.S.A
[10] Rosys, 1113 Forest Run Drive, Batavia, OH 45103, U.S.A

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