Automating combinatorial chemistry: A primer on benchtop robotic systems

被引：10

作者：

Hardin, JH

Smietana, FR

机构：

[1] Lilly Research Laboratories, A Division of Eli Lilly and Co., Lilly Corporate Center, Indianapolis

来源：

MOLECULAR DIVERSITY | 1996年 / 1卷 / 04期

关键词：

robotics; automation; combinatorial chemistry;

D O I：

10.1007/BF01715532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Benchtop robotic systems are inexpensive, flexible automation tools with potential applications in a wide array of disciplines such as combinatorial chemistry, high-throughput screening, and genomics. We explain the basic components of a benchtop system and explore factors to consider when purchasing or customizing a robot, such as automation benefits, vendor selection, and current system limitations. Issues involving system specification, software design, and hardware customization are then discussed. Additionally, system optimization, validation, and support are detailed. Given a properly designed and implemented system, the combinatorial laboratory can markedly increase compound synthesis and purification.

引用

页码：270 / 274

页数：5