In vivo assessment of human visual system connectivity with transcranial electrical stimulation during functional magnetic resonance imaging

被引：16

作者：

Brandt, SA ^{[1
]}

Brocke, J ^{[1
]}

Röricht, S ^{[1
]}

Ploner, CJ ^{[1
]}

Villringer, A ^{[1
]}

Meyer, BU ^{[1
]}

机构：

[1] Charite, Dept Neurol, D-10117 Berlin, Germany

来源：

NEUROIMAGE | 2001年 / 14卷 / 02期

关键词：

transcranial stimulation; fMRI; human visual system; occipital cortex; parietal cortex; frontal cortex; cerebral connectivity;

D O I：

10.1006/nimg.2001.0847

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional magnetic resonance imaging (MRI) was used to investigate local and distant cerebral activation induced by transcranial electrical stimulation in order to noninvasively map functional connectivity in the human visual system. Stimulation with lateromedially directed currents and the anode 4.5 cm dorsally to the inion over the right visual cortex induced phosphenes extending into the contralateral lower quadrant of the visual field. fMRI showed a focal hemodynamic response underneath the anode in extrastriate cortex and distant coactivation in subcortical (lateral geniculate nucleus), cortical visual (striate and extrastriate), and visuomotor areas (frontal and supplementary eye fields). This pattern of activation resembles a network of presumably interconnected visual and visuomotor areas. Analysis of activation sites supplies new information about cerebral correlates of phosphenes and shows that the cortical region underneath the cranial stimulation site is not necessarily the origin of behavioral and/or perceptual effects of transcranial stimulation. We conclude that combining transcranial electrical stimulation of neural tissue with simultaneous fMRI offers the possibility to study noninvasively cerebral connectivity in the human brain. (C) 2001 Academic Press.

引用

页码：366 / 375

页数：10

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