Anti-inflammatory steroids from the octocoral Dendronephthya griffini

被引：24

作者：

Chao, Chih-Hua ^{[1
]}

Wen, Zhi-Hong ^{[1
]}

Chen, I-Ming ^{[1
]}

Su, Jui-Hsin ^{[1
]}

Huang, Ho-Cheng ^{[1
,2
]}

Chiang, Michael Y. ^{[3
]}

Sheu, Jyh-Horng ^{[1
,4
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Cheng Shiu Univ, Dept Chem & Mat Engn, Kaohsiung 833, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[4] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

TETRAHEDRON | 2008年 / 64卷 / 16期

关键词：

octocoral; steroid; griffinisterones A-E; anti-inflammatory effect;

D O I：

10.1016/j.tet.2008.01.109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new steroids, griffinisterones A-E (1-5), were isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. The single-crystal X-ray crystallography on I allowed the determination of the 24R configuration in 1. The absolute stereochemistry of 5 was determined by the application of PGME method. Compounds 3 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory NOS protein of the LPS-stimulated RAW264.7 macrophage cells. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3554 / 3560

页数：7