Two-photon fluorescent probes for acidic vesicles in live cells and tissue

被引:119
作者
Kim, Hwan Myung [1 ]
An, Myoung Jin [1 ]
Hong, Jin Hee [2 ,3 ]
Jeong, Byeong Ha [2 ,3 ]
Kwon, Ohyun [5 ]
Hyon, Ju-Yong [4 ]
Hong, Seok-Cheol [2 ]
Lee, Kyoung J. [2 ,3 ]
Cho, Bong Rae [1 ]
机构
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
[2] Korea Univ, Dept Phys, Seoul 136701, South Korea
[3] Korea Univ, Natl Creat Res Initiat Ctr Neurodynam, Seoul 136701, South Korea
[4] Korea Univ, Biomicrosyst Technol Program, Seoul 136701, South Korea
[5] Samsung Adv Inst Technol, Seoul, South Korea
关键词
acidity; fluorescent probes; live tissue; two-photon microscopy; vesicles;
D O I
10.1002/anie.200704586
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) Move with the groove: Two-photon fluorescent pH probes and a two-photon lysotracker (AL1) can visualize acidic vesicles in live cells and living tissue for a long period of time without mistargeting and photobleaching problems. Using AL1, vesicles can be tracked in real time (see picture). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:2231 / 2234
页数:4
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