Powerful tools for genetic analysis come of age

被引：101

作者：

Graves, DJ ^{[1
]}

机构：

[1] Univ Penn, Dept Chem Engn, Philadelphia, PA 19104 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1999年 / 17卷 / 03期

关键词：

D O I：

10.1016/S0167-7799(98)01241-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microscopic arrays of oligonucleotides or cDNA containing up to several hundred thousand different sequences are starting to influence methodologies and paths to discovery in genomics. Gene polymorphisms and mutations can be found and gene expression measured with unprecedented speed and parallelism. The principles of this modern technology and some of the problems awaiting further study are discussed.

引用

页码：127 / 134

页数：10

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