Synthesis of new cationic lipids from an unsaturated glycoside scaffold

被引：17

作者：

Herscovici, J

Egron, MJ

Quenot, A

Leclercq, F

Leforestier, N

Mignet, N

Wetzer, B

Scherman, D

机构：

[1] ENSCP 11, ENSCP Aventis Gencell, CNRS, UMR 7001,LCBBMC, F-75231 Paris, France

[2] Aventis Gencell CRVA13, F-94403 Vitry Sur Seine, France

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 12期

关键词：

D O I：

10.1021/ol0159423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.

引用

页码：1893 / 1896

页数：4

共 25 条

[21] Synthesis of a single-tailed cationic lipid and investigation of its transfection
Tang, FX
Hughes, JA
[J]. JOURNAL OF CONTROLLED RELEASE, 1999, 62 (03) : 345 - 358
[22] Use of dithiodiglycolic acid as a tether for cationic lipids decreases the cytotoxicity and increases transgene expression of plasmid DNA in vitro
Tang, FX
Hughes, JA
[J]. BIOCONJUGATE CHEMISTRY, 1999, 10 (05) : 791 - 796
[23] Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA
Tang, FX
Hughes, JA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 242 (01) : 141 - 145
[24] Guanidinium-cholesterol cationic lipids: Efficient vectors for the transfection of eukaryotic cells
Vigneron, JP
Oudrhiri, N
Fauquet, M
Vergely, L
Bradley, JC
Basseville, M
Lehn, P
Lehn, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) : 9682 - 9686
[25] Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery
Wang, JK
Guo, X
Xu, YH
Barron, L
Szoka, FC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (13) : 2207 - 2215

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