Microbial Metabolomics

被引：159

作者：

Tang, Jane ^{[1
]}

机构：

[1] Noblis, Ctr Natl Secur & Intelligence, Falls Church, VA 22042 USA

来源：

CURRENT GENOMICS | 2011年 / 12卷 / 06期

关键词：

Metabolomics; metabolome; microbiota; microbiome; systems biology; MASS-SPECTROMETRY; SYSTEMS BIOLOGY; FECAL MICROBIOTA; GENOME; METABOLISM; RECONSTRUCTION; DIVERSITY; DISEASE; METAGENOMICS; BACTERIA;

D O I：

10.2174/138920211797248619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Microbial metabolomics constitutes an integrated component of systems biology. By studying the complete set of metabolites within a microorganism and monitoring the global outcome of interactions between its development processes and the environment, metabolomics can potentially provide a more accurate snap shot of the actual physiological state of the cell. Recent advancement of technologies and post-genomic developments enable the study and analysis of metabolome. This unique contribution resulted in many scientific disciplines incorporating metabolomics as one of their "omics" platforms. This review focuses on metabolomics in microorganisms and utilizes selected topics to illustrate its impact on the understanding of systems microbiology.

引用

页码：391 / 403

页数：13

共 94 条

[1]

A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm [J].

Aderem, Alan ;

Adkins, Joshua N. ;

Ansong, Charles ;

Galagan, James ;

Kaiser, Shari ;

Korth, Marcus J. ;

Law, G. Lynn ;

McDermott, Jason G. ;

Proll, Sean C. ;

Rosenberger, Carrie ;

Schoolnik, Gary ;

Katze, Michael G. .

MBIO, 2011, 2 (01)

[2]

Lessons from Genomics [J].

Alberts, Bruce .

SCIENCE, 2011, 331 (6017) :511-511

[3]

[Anonymous], GENET ENG BIOTECHN N

[4]

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[5]

The Gut's Clostridium Cocktail [J].

Barnes, Michael J. ;

Powrie, Fiona .

SCIENCE, 2011, 331 (6015) :289-290

[6]

Bacterially speaking [J].

Bassler, BL ;

Losick, R .

CELL, 2006, 125 (02) :237-246

[7]

Gene-culture coevolution between cattle milk protein genes and human lactase genes [J].

Beja-Pereira, A ;

Luikart, G ;

England, PR ;

Bradley, DG ;

Jann, OC ;

Bertorelle, G ;

Chamberlain, AT ;

Nunes, TP ;

Metodiev, S ;

Ferrand, N ;

Erhardt, G .

NATURE GENETICS, 2003, 35 (04) :311-313

[8]

New surveyor tools for charting microbial metabolic maps [J].

Breitling, Rainer ;

Vitkup, Dennis ;

Barrett, Michael P. .

NATURE REVIEWS MICROBIOLOGY, 2008, 6 (02) :156-161

[9]

Brindle JT, 2002, NAT MED, V8, P1439, DOI 10.1038/nm802

[10]

Discrimination of pathogenic clinical isolates and laboratory strains of Bacillus cereus by NMR-based metabolomic profiling [J].

Bundy, JG ;

Willey, TL ;

Castell, RS ;

Ellar, DJ ;

Brindle, KM .

FEMS MICROBIOLOGY LETTERS, 2005, 242 (01) :127-136

← 1 2 3 4 5 6 7 8 9 10 →