Model glycol-terminated surfaces for adhesion resistance

被引：7

作者：

Béthencourt, MI ^{[1
]}

Barriet, D ^{[1
]}

Frangi, NM ^{[1
]}

Lee, TR ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, Houston, TX 77204 USA

来源：

JOURNAL OF ADHESION | 2005年 / 81卷 / 10-11期

基金：

美国国家科学基金会;

关键词：

glycol; gold; protein-resistant; SAMs; self-assembled monolayers; surfaces;

D O I：

10.1080/00218460500310762

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This manuscript introduces a new family of cyclic acetal-terminated alkanethiols used to prepare self-assembled monolayers (SAMs) on gold. The new SAMs, which are designed as variants of the biocompatible protein-repellant surfaces generated from thin films of oligoethylene glycol (OEG) or polyethylene glycol (PEG), were characterized by ellipsometry, contact-angle goniometry, and polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS). A preliminary study of protein adhesion was also performed using fibrinogen as a model protein. The interfacial structure and properties of the new SAMs were compared with those generated from OEG-terminated alkanethiols and from surface-grafted PEG, which have been described previously. The data show that the new adsorbates form well packed and conformationally ordered films with contact angles of water ranging from 67 degrees to 95 degrees, depending on the precise structure of the acetal terminus. As a whole, the new SAMs offer a unique strategy for studying and designing adhesion-resistant biocompatible inferfaces.

引用

页码：1031 / 1048

页数：18

共 37 条

[11] Molecular conformation in oligo(ethylene glycol)-terminated self-assembled monolayers on gold and silver surfaces determines their ability to resist protein adsorption [J].