Telomere length and cognitive function in community-dwelling elders: Findings from the Health ABC Study

被引：125

作者：

Yaffe, Kristine ^{[1
,2
,3
,5
]}

Lindquist, Karla ^{[4
]}

Kluse, Molly ^{[1
]}

Cawthon, Richard ^{[6
]}

Harris, Tamara ^{[7
]}

Hsueh, Wen-Chi ^{[4
]}

Simonsick, Eleanor M.

Kuller, Lewis ^{[8
]}

Li, Rongling ^{[9
]}

Ayonayon, Hilsa N. ^{[3
]}

Rubin, Susan M. ^{[3
]}

Cummings, Steven R. ^{[10
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94121 USA

[2] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94121 USA

[3] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA 94121 USA

[4] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94121 USA

[5] San Francisco VA Med Ctr KY, San Francisco, CA 94121 USA

[6] Univ Utah, Dept Human Genet, Salt Lake City, UT 84132 USA

[7] NIA, Lab Epidemiol Demog & Biometty, Intramural Res Program, Bethesda, MD 20892 USA

[8] Univ Pittsburgh, Sch Med, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA

[9] Univ Tennessee, Hlth Sci Ctr, Dept Prevent Med, Memphis, TN 38163 USA

[10] Calif Pacific Med Ctr, San Francisco, CA 94115 USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 11期

关键词：

Cognitive decline; Biomarker; Genetics; Telomeres; Epidemiology; MORTALITY; DISEASE; RISK; ASSOCIATION; LEUKOCYTES; DEMENTIA; SHORTER;

D O I：

10.1016/j.neurobiolaging.2009.12.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Telomere shortening is a marker of cellular aging and has been associated with risk of Alzheimer's disease. Few studies have determined if telomere length is associated with cognitive decline in non-demented elders. We prospectively studied 2734 non-demented elders (mean age: 74 years). We measured cognition with the Modified Mini-Mental State Exam (3MS) and Digit Symbol Substitution Test (DSST) repeatedly over 7 years. Baseline telomere length was measured in blood leukocytes and classified by tertile as "short", "medium", or "long". At baseline, longer telomere length was associated with better DSST score (36.4, 34.9 and 34.4 points for long, medium and short, p < 0.01) but not for change in score. However, 7-year 3MS change scores were less among those with longer telomere length (-1.7 points vs. -2.5 and -2.9, p = 0.01). Findings were similar after multivariable adjustment for age, gender, race, education, assay batch, and baseline score. There was a borderline statistically significant interaction for telomere length and APOE e4 on 3MS change score (p = 0.06). Thus, telomere length may serve as a biomarker for cognitive aging. Published by Elsevier Inc.

引用

页码：2055 / 2060

页数：6

共 30 条

[1] Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
Andrew, T
Aviv, A
Falchi, M
Surdulescu, GL
Gardner, JP
Lu, XB
Kimura, M
Kato, BS
Valdes, AM
Spector, TD
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (03) : 480 - 486
[2] Telomeres and human somatic fitness
Aviv, Abraham
[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (08): : 871 - 873
[3] Neurodegenerative diseases and oxidative stress
Barnham, KJ
Masters, CL
Bush, AI
[J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (03) : 205 - 214
[4] Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease
Bekaert, Sofie
De Meyer, Tim
Rietzschel, Ernst R.
De Buyzere, Marc L.
De Bacquer, Dirk
Langlois, Michel
Segers, Patrick
Cooman, Luc
Van Damme, Piet
Cassiman, Peter
Van Criekinge, Wim
Verdonck, Pascal
De Backer, Guy G.
Gillebert, Thierry C.
Van Oostveldt, Patrick
[J]. AGING CELL, 2007, 6 (05) : 639 - 647
[5] Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
Benetos, A
Gardner, JP
Zureik, M
Labat, C
Lu, XB
Adamopoulos, C
Temmar, M
Bean, KE
Thomas, F
Aviv, A
[J]. HYPERTENSION, 2004, 43 (02) : 182 - 185
[6] Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
Brouilette, Scott W.
Moore, Jasbir S.
D McMahon, Alex
Thompson, John R.
Ford, Ian
Shepherd, James
Packard, Chris J.
Samani, Nilesh J.
[J]. LANCET, 2007, 369 (9556) : 107 - 114
[7] Association between telomere length in blood and mortality in people aged 60 years or older
Cawthon, RM
Smith, KR
O'Brien, E
Sivatchenko, A
Kerber, RA
[J]. LANCET, 2003, 361 (9355) : 393 - 395
[8] Telomere measurement by quantitative PCR
Cawthon, RM
[J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (10) : e47
[9] Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study
Demissie, S.
Levy, D.
Benjamin, E. J.
Cupples, L. A.
Gardner, J. P.
Herbert, A.
Kimura, M.
Larson, M. G.
Meigs, J. B.
Keaney, J. F.
Aviv, A.
[J]. AGING CELL, 2006, 5 (04) : 325 - 330
[10] Accelerated telomere shortening in response to life stress
Epel, ES
Blackburn, EH
Lin, J
Dhabhar, FS
Adler, NE
Morrow, JD
Cawthon, RM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) : 17312 - 17315

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