Human diseases reveal novel roles for neural laminins

被引：72

作者：

Colognato, H

ffrench-Constant, C

Feltri, ML

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[2] Univ Cambridge, Dept Med Genet, Cambridge CB2 1QP, England

[3] SUNY Stony Brook, Dept Pharmacol, Stony Brook, NY 11794 USA

[4] Ist Sci San Raffaele, DIBIT, I-20132 Milan, Italy

来源：

TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tins.2005.07.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS.

引用

收藏

页码：480 / 486

页数：7

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