The role of peroxisomes in aging

被引：50

作者：

Périchon, R

Bourre, JM

Kelly, JF

Roth, GS

机构：

[1] NIA, Cellular & Mol Biol Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA

[2] Hop Fernand Widal, Lab Neuro Pharmaco Nutr, INSERM, U26, F-75475 Paris 10, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1998年 / 54卷 / 07期

关键词：

peroxisome; aging; lipid metabolism; oxidative stress;

D O I：

10.1007/s000180050192

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species and alterations in membrane lipid homeostasis are thought to be important events in aging process and aging-related degenerative diseases. The peroxisome is a small cellular organelle involved in both oxygen and lipid metabolism, and defects in peroxisomal function are associated with major, and often fatal, changes at the neurological level during human development. Recent reports of aging-related changes in peroxisomal function raised the hypothesis that peroxisomes may also have a significant role in the aging process and aging-related degenerative diseases. This review presents the current data on changes in peroxisomal function during aging and discusses the implications of these changes for health.

引用

页码：641 / 652

页数：12

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