Atomistic Simulation and Measurement of pH Dependent Cancer Therapeutic Interactions with Nanodiamond Carrier

被引：105

作者：

Adnan, Ashfaq ^{[6
]}

Lam, Robert ^{[5
]}

Chen, Hanning ^{[4
]}

Lee, Jessica ^{[5
]}

Schaffer, Daniel J.

Barnard, Amanda S. ^{[2
]}

Schatz, George C. ^{[4
]}

Ho, Dean ^{[1
,3
,5
]}

Liu, Wing Kam ^{[1
]}

机构：

[1] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[2] CSIRO Mat Sci & Engn, Clayton, Vic 3168, Australia

[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[5] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[6] Univ Texas Arlington, Dept Mech & Aerosp Engn, Arlington, TX 76019 USA

来源：

MOLECULAR PHARMACEUTICS | 2011年 / 8卷 / 02期

基金：

美国国家科学基金会;

关键词：

nanodiamond; CpHMD; doxorubicine; adsorption; drug delivery; NANOCRYSTALLINE DIAMOND; DYNAMICS; DOXORUBICIN; SURFACE; IMMOBILIZATION; ADSORPTION; ADHESION; DELIVERY; BINDING; BMP-2;

D O I：

10.1021/mp1002398

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this work, we have combined constant-pH molecular dynamics simulations and experiments to provide a quantitative analysis of pH dependent interactions between doxorubicin hydrochloride (DOX) cancer therapeutic and faceted nanodiamond (ND) nanoparticle carriers. Our study suggests that when a mixture of faceted ND and DOX is dissolved in a solvent, the pH of this solvent plays a controlling role in the adsorption of DOX molecules on the ND. We find that the binding of DOX molecules on ND occurs only at high pH and requires at least similar to 10% of ND surface area to be fully titrated for binding to occur. As such, this study reveals important mechanistic insight underlying an ND-based pH-controlled therapeutic platform.

引用

页码：368 / 374

页数：7

共 36 条

[31]

SHENDEROVA OA, 2006, UTRANANOCRYSTALLINE

[32] Nanodiamond-insulin complexes as pH-dependent protein delivery vehicles [J].

Shimkunas, Rafael A. ;

Robinson, Erik ;

Lam, Robert ;

Lu, Steven ;

Xu, Xiaoyang ;

Zhang, Xue-Qing ;

Huang, Houjin ;

Osawa, Eiji ;

Ho, Dean .

BIOMATERIALS, 2009, 30 (29) :5720-5728

[33] TRANSPORT STUDIES OF DOXORUBICIN IN MODEL MEMBRANES INDICATE A DIFFERENCE IN PASSIVE DIFFUSION ACROSS AND BINDING AT THE OUTER AND INNER LEAFLETS OF THE PLASMA-MEMBRANE [J].

SPEELMANS, G ;

STAFFHORST, RWHM ;

DEKRUIJFF, B ;

DEWOLF, FA .

BIOCHEMISTRY, 1994, 33 (46) :13761-13768

[34] Strong binding of bioactive BMP-2 to nanocrystalline diamond by physisorption [J].

Steinmueller-Nethl, Doris ;

Kloss, Frank R. ;

Najam-U-Haq, Muhammed ;

Rainer, Matthias ;

Larsson, Karin ;

Linsmeier, Christian ;

Koehler, Gottfried ;

Fehrer, Christine ;

Lepperdinger, Guenter ;

Liu, Xianjie ;

Memmel, Norbert ;

Bertel, Erminald ;

Huck, Christian W. ;

Gassner, Robert ;

Bonn, Guenther .

BIOMATERIALS, 2006, 27 (26) :4547-4556

[35] MODELING SOLID-STATE CHEMISTRY - INTERATOMIC POTENTIALS FOR MULTICOMPONENT SYSTEMS [J].

TERSOFF, J .

PHYSICAL REVIEW B, 1989, 39 (08) :5566-5568

[36] Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery [J].

Zhang, Xue-Qing ;

Chen, Mark ;

Lam, Robert ;

Xu, Xiaoyang ;

Osawa, Eiji ;

Ho, Dean .

ACS NANO, 2009, 3 (09) :2609-2616

← 1 2 3 4 →