New antivirals - mechanism of action and resistance development

被引:42
作者
Balzarini, J [1 ]
Naesens, L [1 ]
De Clercq, E [1 ]
机构
[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
关键词
D O I
10.1016/S1369-5274(98)80086-6
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In recent years, several novel treatment modalities emerged for a number of virus infections, including lamivudine for hepatitis B virus, abacavir, adefovir dipivoxyl and apropovir disprometil for human immunodeficiency virus, cidofovir for cytomegalovirus, and famciclovir (the oral prodrug of penciclovir) and cidofovir for other herpesviruses (i.e. herpes simplex virus and varicella-zoster virus). For all drugs, resistance eventually develops upon prolonged administration to the infected individuals, albeit to a varying extent. In addition, new mutations related to multidrug resistance have recently been identified.
引用
收藏
页码:535 / 546
页数:12
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