New antivirals - mechanism of action and resistance development

被引：42

作者：

Balzarini, J ^{[1
]}

Naesens, L ^{[1
]}

De Clercq, E ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(98)80086-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In recent years, several novel treatment modalities emerged for a number of virus infections, including lamivudine for hepatitis B virus, abacavir, adefovir dipivoxyl and apropovir disprometil for human immunodeficiency virus, cidofovir for cytomegalovirus, and famciclovir (the oral prodrug of penciclovir) and cidofovir for other herpesviruses (i.e. herpes simplex virus and varicella-zoster virus). For all drugs, resistance eventually develops upon prolonged administration to the infected individuals, albeit to a varying extent. In addition, new mutations related to multidrug resistance have recently been identified.

引用

页码：535 / 546

页数：12

共 73 条

[21] EIZURI Y, 1998, INT ANTIVIRAL NEWS, V6, P61
[22] Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients
Erice, A
GilRoda, C
Perez, JL
Balfour, HH
Sannerud, KJ
Hanson, MN
Boivin, G
Chou, SW
[J]. JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (05) : 1087 - 1092
[23] Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
Faletto, MB
Miller, WH
Garvey, EP
Clair, MHS
Daluge, SM
Good, SS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) : 1099 - 1107
[24] Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] in vitro
Fischer, KP
Tyrrell, DLJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) : 1957 - 1960
[25] Role of additional mutations outside the YMDD motif of hepatitis B virus polymerase in L(-)SddC (3TC) resistance
Fu, L
Cheng, YC
[J]. BIOCHEMICAL PHARMACOLOGY, 1998, 55 (10) : 1567 - 1572
[26] SUSCEPTIBILITIES OF ZIDOVUDINE-RESISTANT VARIANTS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO INHIBITION BY ACYCLIC NUCLEOSIDE PHOSPHONATES
GONG, YF
MARSHALL, DR
SRINIVAS, RV
FRIDLAND, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) : 1683 - 1687
[27] GOOD SS, 1995, ANTIVIR RES, V26, pA229
[28] K65R MUTATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE ENCODES CROSS-RESISTANCE TO 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE
GU, ZX
SALOMON, H
CHERRINGTON, JM
MULATO, AS
CHEN, MS
YARCHOAN, R
FOLI, A
SOGOCIO, KM
WAINBERG, MA
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (08) : 1888 - 1891
[29] Günthard HF, 1998, J VIROL, V72, P2422
[30] Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir
Harada, K
Eizuru, Y
Isashiki, Y
Ihara, S
Minamishima, Y
[J]. ARCHIVES OF VIROLOGY, 1997, 142 (02) : 215 - 225

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