A convenient synthesis of the beraprost intermediate: A useful method for introducing a C3 unit at the benzyl position

被引：27

作者：

Higuchi, K

Sawada, K

Nambu, H

Shogaki, T

Kita, Y

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Sawai Pharmaceut Co Ltd, Asahi Ku, Osaka 5350005, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 20期

关键词：

D O I：

10.1021/ol035371+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Heck reaction is a more efficient and reliable method than previous ones for introducing a C3 unit at the benzyl position for the synthesis of Beraprost. Especially, trialkylated long-chain amines such as (n-C8H17)(3)N and (n-C12H25)(3)N resulted in good yields. This development will be used for the industrial synthesis of Beraprost.

引用

页码：3703 / 3704

页数：2

共 26 条

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