A formal synthesis of (+)-discodermolide

被引：17

作者：

Loiseleur, O ^{[1
]}

Koch, G ^{[1
]}

Cercus, J ^{[1
]}

Schürch, F ^{[1
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 03期

关键词：

D O I：

10.1021/op049807s

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we report the formal synthesis of (+)-discodermolide (1), a promising anticancer agent of sponge origin, in 24 linear steps, with 35 steps in total. The route proceeds from lactone 2, a building block containing the common 1,2-anti-2,3-syn stereotriad found in each of the three subunits, methyl ketone 4 (C-1-C-6), vinyl iodide 7 (C-9--C-14), and iodide 8 (C-15-C-24) utilized for the construction of L The key fragment union was achieved by a Suzuki cross-coupling between 7 and 8.

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页码：259 / 271

页数：13

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