Effusion cytology in ovarian cancer: new molecular methods as aids to diagnosis and prognosis

被引：42

作者：

Davidson, B ^{[1
]}

Risberg, B

Reich, R

Berner, A

机构：

[1] Univ Oslo, Norwegian Radium Hosp, Dept Pathol, N-0310 Oslo, Norway

[2] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Dept Pharmacol & Expt Therapeut, IL-91120 Jerusalem, Israel

来源：

CLINICS IN LABORATORY MEDICINE | 2003年 / 23卷 / 03期

关键词：

D O I：

10.1016/S0272-2712(03)00058-1

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Carcinoma of the ovary is the leading cause of death from gynecologic cancer in western countries. Ovarian carcinoma is commonly associated with the accumulation of fluid that contains malignant cells in the peritoneal and pleural cavities. This article details the current knowledge regarding the diagnostic and biologic characteristics of ovarian carcinoma cells in effusions, and the genotypic and phenotypic differences between solid primary tumors and metastatic lesions. Finally, we present a new approach, by which the analysis of fresh frozen viable cells allows us to study in vivo the links between expression and activity of extracellular mediators, membrane receptors, intracellular signaling, and transcription factors, and their potential therapeutic and prognostic significance.

引用

页码：729 / +

页数：27

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