Arachidonoylcholine and N,N-dimethylaminoethyl arachidonate, new cholinergic compounds

被引:10
作者
Bezuglov, VV
Zinchenko, GN
Nikitina, LA
Buznikov, GA
机构
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
[2] Russian Acad Sci, NK Koltsov Dev Biol Inst, Moscow 117808, Russia
基金
俄罗斯基础研究基金会;
关键词
arachidonic acid; nicotine; choline esters; sea urchin;
D O I
10.1023/A:1011341623358
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Choline and N,N-dimethylaminoethyl esters of arachidonic and some other fatty acids were synthesized. Experiments on the embryos and larvae of sea urchins, sensitive to cholinergic compounds, showed that arachidonoylcholine exhibited cholinomimetic activity similar to that of nicotine while N,N-dimethylaminoethyl arachidonate acted as acetylcholine antagonist. The corresponding esters of docosahexaenoic acid were found to manifest similar biological properties.
引用
收藏
页码:200 / 203
页数:4
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