An open and closed case for all polymerases

被引：281

作者：

Doublié, S

Sawaya, MR

Ellenberger, T

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Univ Vermont, Markey Ctr Mol Genet, Dept Microbiol & Mol Genet, Burlington, VT 05405 USA

来源：

STRUCTURE | 1999年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0969-2126(99)80017-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recently determined structures of HIV-1 reverse transcriptase and Taq DNA polymerase in complex with DNA primer-template and an incoming nucleotide have shown that a large conformational change configures the polymerase active site for nucleotidyl transfer. The structure of reverse transcriptase in the catalytic complex will open the path to the rational design of novel nucleoside analog inhibitors of viral replication.

引用

页码：R31 / R35

页数：5

共 22 条

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