Mediator and the mechanism of transcriptional activation

被引：455

作者：

Kornberg, RD ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 05期

关键词：

D O I：

10.1016/j.tibs.2005.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system - it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer -> activator -> Mediator -> pol II -> promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.

引用

页码：235 / 239

页数：5

共 32 条

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