Objective: To investigate the relationship between soluble cellular adhesion molecules (sCAMs) and the extent of coronary artery disease (CAD) in patients with stable angina pectoris. Methods and results: Two hundred and ninety-one subjects had fasting levels of circulating intercellular adhesion molecule-1(sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1), sP-selectin and contents of n-3 polyunsaturated fatty acids (n-3 PUFA) in granulocyte membranes and adipose tissue determined before undergoing elective coronary angiography. Levels of soluble VCAM-1 (983 216 versus 893 +/- 196ng/l, p < 0.001), ICAM-1 (318 +/- 140 versus 290 +/- 75 ng/l, p < 0.05) and P-selectin (90 +/- 27 versus 80 +/- 23 ng/l, p < 0.01) were significantly increased in subjects with significant CAD compared to subjects with no significant stenoses. In a linear regression analysis, both sVCAM-1 and sP-selectin, but not sICAM-1, correlated to the presence and the severity of CAD. Both sICAM-1 and sP-selectin were significantly correlated to current smoking status and a history of myocardial infarction. The content of total n-3 PUFA and docosahexaenoic acid in adipose tissue was marginally, but significant positively correlated to VCAM-1. Conclusion: sVCAM-1 and sP-selectin may serve as markers of CAD in patients with stable angina pectoris. Only sVCAM-1 was weakly correlated to n-3 PUFA in adipose tissue. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
机构:
Univ Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, EnglandUniv Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, England
Blann, AD
;
Nadar, SK
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Univ Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, EnglandUniv Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, England
Nadar, SK
;
Lip, GYH
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机构:
Univ Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, EnglandUniv Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, England
机构:
Univ Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, EnglandUniv Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, England
Blann, AD
;
Nadar, SK
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机构:
Univ Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, EnglandUniv Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, England
Nadar, SK
;
Lip, GYH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, EnglandUniv Birmingham, City Hosp, Dept Med, Haemostasis Thromosis & Vasc Biol Unit, Birmingham, W Midlands, England