Soluble adhesion molecules and marine n-3 fatty acids in patients referred for coronary angiography

被引:21
作者
Eschen, O [1 ]
Christensen, JH
Toft, E
Schmidt, EB
机构
[1] Aarhus Univ Hosp, Aalborg Sygehus, Dept Cardiol, Ctr Cardiovasc Res, Aalborg, Denmark
[2] Aarhus Univ Hosp, Aalborg Sygehus, Dept Nephrol, Aalborg, Denmark
[3] Aalborg Univ, Dept Hlth Sci & Technol, SMI, Aalborg, Denmark
关键词
soluble cellular adhesion molecule; fatty acids; angiography;
D O I
10.1016/j.atherosclerosis.2004.12.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To investigate the relationship between soluble cellular adhesion molecules (sCAMs) and the extent of coronary artery disease (CAD) in patients with stable angina pectoris. Methods and results: Two hundred and ninety-one subjects had fasting levels of circulating intercellular adhesion molecule-1(sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1), sP-selectin and contents of n-3 polyunsaturated fatty acids (n-3 PUFA) in granulocyte membranes and adipose tissue determined before undergoing elective coronary angiography. Levels of soluble VCAM-1 (983 216 versus 893 +/- 196ng/l, p < 0.001), ICAM-1 (318 +/- 140 versus 290 +/- 75 ng/l, p < 0.05) and P-selectin (90 +/- 27 versus 80 +/- 23 ng/l, p < 0.01) were significantly increased in subjects with significant CAD compared to subjects with no significant stenoses. In a linear regression analysis, both sVCAM-1 and sP-selectin, but not sICAM-1, correlated to the presence and the severity of CAD. Both sICAM-1 and sP-selectin were significantly correlated to current smoking status and a history of myocardial infarction. The content of total n-3 PUFA and docosahexaenoic acid in adipose tissue was marginally, but significant positively correlated to VCAM-1. Conclusion: sVCAM-1 and sP-selectin may serve as markers of CAD in patients with stable angina pectoris. Only sVCAM-1 was weakly correlated to n-3 PUFA in adipose tissue. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:327 / 331
页数:5
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