PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample

被引：11

作者：

Bertram, L

Menon, R

Mullin, K

Parkinson, M

Bradley, ML

Blacker, D

Tanzi, RE

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp,Dept Neurol, Ctr Aging Genet & Neurodegenerat,Genet & Aging Re, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat,Gerontol Res Unit, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

NEUROLOGY | 2004年 / 62卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000103283.65914.0B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

PEN2 is a reasonable Alzheimer's disease (AD) candidate gene because it is a necessary component of the gamma-secretase complex that generates beta-amyloid peptide. Moreover, its gene (PEN2) maps to a highly significant linkage region on chromosome 19q13. Four common polymorphisms in PEN2 were tested for genetic association with AD in a large and carefully ascertained AD family sample (789 subjects from 202 nuclear families) using single-locus and haplotype-based analyses. These results do not suggest PEN2 to be a major AD risk factor.

引用

页码：304 / 306

页数：3

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