Thioglycosynthases:: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis

被引：52

作者：

Jahn, M

Chen, HM

Müllegger, J

Marles, J

Warren, RAJ

Withers, SG

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 03期

关键词：

D O I：

10.1039/b313155f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A double mutant, retaining glycosidase that lacks both the catalytic nucleophile and the catalytic acid/base residues efficiently catalyzes thioglycoside formation from a glycosyl fluoride donor and thiosugar acceptors.

引用

页码：274 / 275

页数：2

共 12 条

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