Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling

被引：77

作者：

Lehmler, HJ ^{[1
]}

Robertson, LW ^{[1
]}

机构：

[1] Univ Kentucky, Grad Ctr Toxicol, Chandler Med Ctr, Lexington, KY 40536 USA

来源：

CHEMOSPHERE | 2001年 / 45卷 / 08期

关键词：

PCB; Suzuki-coupling; environmental contaminants;

D O I：

10.1016/S0045-6535(01)00052-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB, congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high selectivity and good yields compared to conventional methods such as the Cadogan reaction and allows the use of less toxic starting materials. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1119 / 1127

页数：9

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