Restless Legs Syndrome-Associated MEIS1 Risk Variant Influences Iron Homeostasis

被引：65

作者：

Catoire, Helene ^{[1
]}

Dion, Patrick A. ^{[1
,2
]}

Xiong, Lan ^{[1
,3
]}

Amari, Mourabit ^{[1
]}

Gaudet, Rebecca ^{[1
]}

Girard, Simon L. ^{[1
]}

Noreau, Anne ^{[1
]}

Gaspar, Claudia ^{[1
,2
]}

Turecki, Gustavo ^{[4
]}

Montplaisir, Jacques Y. ^{[5
,6
]}

Parker, J. Alex ^{[1
,2
]}

Rouleau, Guy A. ^{[1
,3
,7
,8
]}

机构：

[1] Univ Montreal, CHUM Res Ctr, Ctr Excellence Neur, Montreal, PQ, Canada

[2] Univ Montreal, Fac Med, Dept Pathol & Cell Biol, Montreal, PQ H3C 3J7, Canada

[3] Univ Montreal, Fac Med, Dept Med, Montreal, PQ H3C 3J7, Canada

[4] McGill Univ, Douglas Mental Hlth Univ Inst, McGill Grp Suicide Studies, Montreal, PQ, Canada

[5] Hop Sacre Coeur, Ctr Etude Sommeil, Montreal, PQ H4J 1C5, Canada

[6] Univ Montreal, Neurol Sci Res Ctr, Montreal, PQ, Canada

[7] Univ Montreal, Dept Pediat & Biochem, Montreal, PQ, Canada

[8] Univ Montreal, Res Ctr, CHU St Justine, Montreal, PQ, Canada

来源：

ANNALS OF NEUROLOGY | 2011年 / 70卷 / 01期

基金：

加拿大健康研究院;

关键词：

CAENORHABDITIS-ELEGANS; BRAIN IRON; FERRITIN; TRANSFERRIN; EXPRESSION; GENES;

D O I：

10.1002/ana.22435

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Restless legs syndrome (RLS) is a frequent sleep disorder that is linked to disturbed iron homeostasis. Genetic studies identified MEIS1 as an RLS-predisposing gene, where the RLS risk haplotype is associated with decreased MEIS1 mRNA and protein expression. We show here that RNA interference treatment of the MEIS1 worm orthologue increases ferritin expression in Caenorhabditis elegans and that the RLS-associated haplotype leads to increased expression of ferritin and DMT1 in RLS brain tissues. Additionally, human cells cultured under iron-deficient conditions show reduced MEIS1 expression. Our data establish a link between the RLS MEIS1 gene and iron metabolism. ANN NEUROL 2011;70:170-175

引用

页码：170 / 175

页数：6

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