Endogenous cannabinoids: Structure and metabolism

被引：94

作者：

Bisogno, T. ^{[1
]}

机构：

[1] CNR, Ist Chim Biomol, Endocannabinoid Res Grp, Naples, Italy

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2008年 / 20卷

关键词：

endocannabinoids; anandamide; 2-arachidonoylglycerol;

D O I：

10.1111/j.1365-2826.2008.01676.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The finding of specific binding sites for Delta(9)-tetrahydrocannabinol, the psychoactive component of Cannabis sativa, has led to the discovery of the endocannabinoid system and has emphasised the physiological and pathological relevance of endocannabidoid lipid signalling. Subsequently, an increasing number of papers have been published on the biochemistry and pharmacology of endocannabinoids. An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation.

引用

页码：1 / 9

页数：9

共 63 条

[1] Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity [J].

Ahn, Kyunghye ;

Johnson, Douglas S. ;

Fitzgerald, Laura R. ;

Liimatta, Marya ;

Arendse, Andrea ;

Stevenson, Tracy ;

Lund, Eric. T. ;

Nugent, Richard A. ;

Nomanbhoy, Tyzoon K. ;

Alexander, Jessica P. ;

Cravatt, Benjamin F. .

BIOCHEMISTRY, 2007, 46 (45) :13019-13030

[2] Functional role of high-affinity anandamide transport, as revealed by selective inhibition [J].

Beltramo, M ;

Stella, N ;

Calignano, A ;

Lin, SY ;

Makriyannis, A ;

Piomelli, D .

SCIENCE, 1997, 277 (5329) :1094-1097

[3] Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain [J].

Bisogno, T ;

Howell, F ;

Williams, G ;

Minassi, A ;

Cascio, MG ;

Ligresti, A ;

Matias, I ;

Schiano-Moriello, A ;

Paul, P ;

Williams, EJ ;

Gangadharan, U ;

Hobbs, C ;

Di Marzo, V ;

Doherty, P .

JOURNAL OF CELL BIOLOGY, 2003, 163 (03) :463-468

[4] Development of the first potent and specific inhibitors of endocannabinoid biosynthesis [J].

Bisogno, T ;

Cascio, MG ;

Saha, B ;

Mahadevan, A ;

Urbani, P ;

Minassi, A ;

Appendino, G ;

Saturnino, C ;

Martin, B ;

Razdan, R ;

Di Marzo, V .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2006, 1761 (02) :205-212

[5] Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin [J].

Bisogno, T ;

Melck, D ;

De Petrocellis, L ;

Di Marzo, V .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (05) :2113-2119

[6] N-acyl-dopamines:: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo [J].

Bisogno, T ;

Melck, D ;

Bobrov, MY ;

Gretskaya, NM ;

Bezuglov, VV ;

De Petrocellis, L ;

Di Marzo, V .

BIOCHEMICAL JOURNAL, 2000, 351 (03) :817-824

[7] Brain regional distribution of endocannabinoids: Implications for their biosynthesis and biological function [J].

Bisogno, T ;

Berrendero, F ;

Ambrosino, G ;

Cebeira, M ;

Ramos, JA ;

Fernandez-Ruiz, JJ ;

Di Marzo, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 256 (02) :377-380

[8]

Cadas H, 1997, J NEUROSCI, V17, P1226

[9] Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism [J].

Carrier, EJ ;

Kearn, CS ;

Barkmeier, AJ ;

Breese, NM ;

Yang, WQ ;

Nithipatikom, K ;

Pfister, SL ;

Campbell, WB ;

Hillard, CJ .

MOLECULAR PHARMACOLOGY, 2004, 65 (04) :999-1007

[10] Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides [J].

Cravatt, BF ;

Giang, DK ;

Mayfield, SP ;

Boger, DL ;

Lerner, RA ;

Gilula, NB .

NATURE, 1996, 384 (6604) :83-87

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