The yin and yang of E2F-1: balancing life and death

被引：97

作者：

La Thangue, NB ^{[1
]}

机构：

[1] Univ Glasgow, Div Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ncb0703-587

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

E2F transcription factors coordinate the timely expression of genes during early cell-cycle progression. In addition, the E2F-1 subunit can induce apoptosis in response to DNA damage. New results reveal an unexpected function for E2F-1 in suppressing apoptosis, which may be important in explaining the contribution of E2F-1 to tumorigenesis.

引用

页码：587 / 589

页数：3

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