Structure-function relationship of follicle-stimulating hormone and its receptor

被引:67
作者
Ulloa-Aguirre, A [1 ]
Timossi, C [1 ]
机构
[1] Inst Nacl Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico
关键词
FSH; FSH receptor; function; structure;
D O I
10.1093/humupd/4.3.260
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Follicle stimulating hormone (FSH) is one of the two pituitary gonadotrophins involved in the regulation of gonadal function. Structurally, this gonadotrophin is a heterodimer composed of two non-covalently associated subunits containing several heterogenous oligosaccharide residues which play an important role in both the in-vivo and in-vitro bioactivity of the hormone. Its cognate receptor, which belongs to the superfamily of the G protein-linked cell surface receptors, also displays a high degree of functional and molecular complexity, Studies employing monoclonal antibodies, synthetic peptides and/or site directed mutagenesis, have unveiled some of the multiple structural determinants involved in FSH and FSH receptor function and interaction. Despite their structural complexity, both molecules exhibit a high degree of plasticity and diversity that allows formation of distinct ligand-receptor complexes capable of selectively activating or deactivating a variety of signalling pathways. Knowledge and mapping of the structural determinants and functional epitopes for intra- and extracellular hormone action are of paramount importance not only for a better and more detailed understanding of the molecular basis of FSH action and FSH receptor function but also for the rational design of analogues with predicted properties and effects.
引用
收藏
页码:260 / 283
页数:24
相关论文
共 270 条
[61]   RHODOPSIN MUTANTS THAT BIND BUT FAIL TO ACTIVATE TRANSDUCIN [J].
FRANKE, RR ;
KONIG, B ;
SAKMAR, TP ;
KHORANA, HG ;
HOFMANN, KP .
SCIENCE, 1990, 250 (4977) :123-125
[62]   STUDIES ON THE DISULFIDE BONDS IN HUMAN PITUITARY FOLLICLE-STIMULATING-HORMONE [J].
FUJIKI, Y ;
RATHNAM, P ;
SAXENA, BB .
BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 624 (02) :428-435
[63]   Disulfide bonds 7-31 and 59-87 of the alpha-subunit play a different role in assembly of human chorionic gonadotropin and lutropin [J].
Furuhashi, M ;
Suzuki, S ;
Suganuma, N .
ENDOCRINOLOGY, 1996, 137 (10) :4196-4200
[64]   INVITRO AND INVIVO BIOACTIVITY OF RECOMBINANT HUMAN FOLLICLE-STIMULATING-HORMONE AND PARTIALLY DEGLYCOSYLATED VARIANTS SECRETED BY TRANSFECTED EUKARYOTIC CELL-LINES [J].
GALWAY, AB ;
HSUEH, AJW ;
KEENE, JL ;
YAMOTO, M ;
FAUSER, BCJM ;
BOIME, I .
ENDOCRINOLOGY, 1990, 127 (01) :93-100
[65]   SEX STEROID-HORMONE REGULATION OF FOLLICLE-STIMULATING-HORMONE SUBUNIT MESSENGER-RIBONUCLEIC-ACID (MESSENGER-RNA) LEVELS IN THE RAT [J].
GHARIB, SD ;
WIERMAN, ME ;
BADGER, TM ;
CHIN, WW .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (02) :294-299
[66]   ANDROGENS POSITIVELY REGULATE FOLLICLE-STIMULATING-HORMONE BETA-SUBUNIT MESSENGER-RNA LEVELS IN RAT PITUITARY-CELLS [J].
GHARIB, SD ;
LEUNG, PCK ;
CARROLL, RS ;
CHIN, WW .
MOLECULAR ENDOCRINOLOGY, 1990, 4 (11) :1620-1626
[67]   MOLECULAR-BIOLOGY OF THE PITUITARY GONADOTROPINS [J].
GHARIB, SD ;
WIERMAN, ME ;
SHUPNIK, MA ;
CHIN, WW .
ENDOCRINE REVIEWS, 1990, 11 (01) :177-199
[68]   ISOLATION AND CHARACTERIZATION OF THE GENE ENCODING THE BETA-SUBUNIT OF RAT FOLLICLE-STIMULATING-HORMONE [J].
GHARIB, SD ;
ROY, A ;
WIERMAN, ME ;
CHIN, WW .
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1989, 8 (05) :339-349
[69]   The luteinizing hormone chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals [J].
Gilchrist, RL ;
Ryu, KS ;
Ji, IH ;
Ji, TH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (32) :19283-19287
[70]  
GODINE JE, 1982, J BIOL CHEM, V257, P8368