Review role of liquid chromatography-mass spectrometry in the analysis of oxidation products and antioxidants in biological systems

This review covers the applications of mass spectrometry with sample introduction in the liquid phase to the analysis of the oxidation products of DNA, proteins and lipids in vitro and in vivo. The analysis of antioxidant xenobiotics in biological systems is also covered. The review covers the period 1997-late 2002. The most commonly used mass spectrometric mode used in this area of study is electrospray mass spectrometry that may also include collision-induced dissociation (CID). The review summarises for each paper the important methodological aspects of the techniques used and, where appropriate, the importance of the observations made within the context of biology. (C) 2003 Elsevier B.V. All rights reserved.