Non-inhibition of acetylcholinesterase by cycloSal nucleotides

被引：7

作者：

Ducho, C

Balzarini, J

Meier, C

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

AChE; cycloSal; inhibition; pronucleotides;

D O I：

10.1081/NCN-120022667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An acetylcholinesterase (AChE) assay based oil the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. No inhibition was observed in any of the cases.

引用

页码：841 / 843

页数：3