Lupus erythematosus profundus (lupus panniculitis) induced by interferon-β in a multiple sclerosis patient

被引：12

作者：

Gono, Takahisa

Matsuda, Masayuki

Shimojima, Yasuhiro

Kaneko, Kazurna

Murata, Hiroshi

Ikeda, Shu-Ichi

机构：

[1] Shinshu Univ, Sch Med, Dept Internal Med, Matsumoto, Nagano 390, Japan

[2] Shinshu Univ, Sch Med, Dept Dermatol, Matsumoto, Nagano, Japan

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2007年 / 14卷 / 10期

关键词：

interferon-beta; lupus erythematosus profundus; multiple sclerosis;

D O I：

10.1016/j.jocn.2006.07.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a patient with multiple sclerosis (MS) who developed subcutaneous nodules on the face, shoulders and extremities while being treated with interferon (IFN)-beta-1b. These nodules fluctuated in parallel with myelopathy, and were diagnosed as lupus erythematosus profundus (LEP) based on histopathological findings. The patient showed no relapse of either neurological symptoms or subcutaneous nodules after cessation of (IFN)-beta-1b. This agent can cause induration and necrosis in the sites of injection but also systemic skin lesions such as LEP ascribable to its immunomodulatory effects. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：997 / 1000

页数：4

共 14 条

[1]

Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].