Ku70: A candidate tumor suppressor gene for murine T cell lymphoma

被引：188

作者：

Li, GC

Ouyang, HH

Li, XL

Nagasawa, H

Little, JB

Chen, DJ

Ling, CC

Fuks, Z

Cordon-Cardo, C

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Phys Med, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[4] Harvard Univ, Sch Publ Hlth, Radiobiol Lab, Boston, MA 02115 USA

[5] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

来源：

MOLECULAR CELL | 1998年 / 2卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(00)80108-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70(-/-) mouse fibroblasts displayed an increased rate of sister chromatid exchange and a high frequency of spontaneous neoplastic transformation. In vivo, Ku70(-/-) mice, known to be defective in B but not T lymphocyte maturation, developed thymic and disseminated T cell lymphomas at a mean age of 6 months with CD4(+)CD8(+) tumor cells. These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression.

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页码：1 / 8

页数：8

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