The BioGRID Interaction Database: 2011 update

被引：663

作者：

Stark, Chris ^{[1
]}

Breitkreutz, Bobby-Joe ^{[1
]}

Chatr-aryamontri, Andrew ^{[2
]}

Boucher, Lorrie ^{[1
]}

Oughtred, Rose ^{[3
]}

Livstone, Michael S. ^{[3
]}

Nixon, Julie ^{[2
]}

Van Auken, Kimberly ^{[4
]}

Wang, Xiaodong ^{[4
]}

Shi, Xiaoqi ^{[5
]}

Reguly, Teresa ^{[1
]}

Rust, Jennifer M. ^{[3
]}

Winter, Andrew ^{[2
]}

Dolinski, Kara ^{[3
]}

Tyers, Mike ^{[1
,2
]}

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, Scotland

[3] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[4] CALTECH, Div Biol, Pasadena, CA 91125 USA

[5] Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

COMPREHENSIVE RESOURCE; GENE; NETWORKS;

D O I：

10.1093/nar/gkq1116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans (http://www.thebiogrid.org). BioGRID currently holds 347 966 interactions (170 162 genetic, 177 804 protein) curated from both high-throughput data sets and individual focused studies, as derived from over 23 000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe) and thale cress (Arabidopsis thaliana), and efforts to expand curation across multiple metazoan species are underway. The BioGRID houses 48 831 human protein interactions that have been curated from 10 247 publications. Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources. An automated Interaction Management System (IMS) is used to prioritize, coordinate and track curation across international sites and projects. BioGRID provides interaction data to several model organism databases, resources such as Entrez-Gene and other interaction meta-databases. The entire BioGRID 3.0 data collection may be downloaded in multiple file formats, including PSI MI XML. Source code for BioGRID 3.0 is freely available without any restrictions.

引用

页码：D698 / D704

页数：7

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